Special Agent Strahm is dead, and Detective Hoffman has emerged as the unchallenged successor to Jigsaw's legacy. However, when the FBI draws closer to Hoffman, he is forced to set a game into motion, and Jigsaw's grand scheme is finally understood.

When the Chase family moves to an isolated house in the middle of nowhere in Detroit, Arkin is hired to fix the windows and the doors. Later he meets his daughter and his wife that has a debt with dangerous sharks and needs money, but his week payment is not enough to pay her debts. Arkin plots to heist the safe of Michael Chase during the night to raise the necessary money. However, when he arrives in the house, he finds that a sadistic criminal has imprisoned the family and planted traps everywhere. Arkin seeks a way out of the deadly house to save his life.

In a remote bar, a newcomer advises the customers to seal the place up, as hungry monsters will soon attack them. The customers must quickly organize a strategy to defend themselves from the deadly creatures.

Jigsaw and his young apprentice, Amanda, are dead. But the grisly games continue. 5 supposed strangers find themselves in the midst of the big game, and believe they are in a survival of the fittest competition. Via his now infamous video linked doll, Jigsaw conveys the message that they should ignore there instincts, and ignore his advice at their peril. Meanwhile, agent Strahm wants to prove that Hoffman is an apprentice to Jigsaw, and pursues him as he continues his twisted games. What Strahm does not realize is that Hoffman is testing him all along, and must pass his test in order to stay alive.

The monsters have made it into a small neighboring town in the middle of nowhere and the locals have to band with the survivors of the bar' slaughter to figure out how to survive.